Samuel I. Mann

This paper designs a de novo protein to stabilize a Mn(V)-nitrido complex and demonstrates its use in enantioselective aziridination with high turnover and enantiomeric ratio.

This paper designs de novo Rhodamine Binder (Rhobin) tags with high brightness, stability, and applicability in live-cell imaging and extreme conditions.

This paper designs a protein to bind naphthalenediimides and evaluates its ability to generate reactive species for proximity labeling.

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.