Sophia K. Tan

This study shows how a designed generalist binding protein can evolve into specific functions like a fluorophore binder and an efficient enzyme through weak, promiscuous interactions.

The paper introduces NOVARK, an ultrabright biosensor for dynamic imaging of kinase activity, showing it can detect phosphorylation-induced assembly with higher brightness and dynamic range than existing methods.

This paper designs de novo proteins to modify nanopore complexes, creating customized structural and functional properties for enhanced sequencing applications.

This paper designs a protein to bind naphthalenediimides and evaluates its ability to generate reactive species for proximity labeling.

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.

This paper introduces a computational method to design peptides that bind specific conformers of α-synuclein fibrils, resulting in a peptide that slows amyloid formation and shows high specificity.

The paper uses deep mutational scanning to explore how chemical perturbations affect ubiquitin's mutational tolerance, revealing sensitization of most positions except two.