Norman van Rhijn

This study develops an ex vivo porcine corneal model to evaluate combined natamycin and PACK-CXL treatment for fungal keratitis, showing it reduces fungal burden more effectively than either treatment alone.

The paper isolates Candida auris from Antarctica, identifies cold-adapted traits, and links mutator phenotypes to rapid evolution and drug resistance in global C. auris clades.

This study investigates β-1,6-glucan biosynthesis in Aspergillus fumigatus, showing it occurs only in conidia and is regulated by the Kre6 gene.

This study demonstrates that G-quadruplexes are a promising antifungal target, as ligands like PhenDC3 inhibit fungal pathogens and show synergistic effects with existing antifungals.

This study identifies a mutation rate increase in a multi-azole resistant Aspergillus fumigatus clade, linking it to rapid antifungal resistance evolution.

The paper investigates Aspergillus species distribution and triazole susceptibility in clinical, soil, and veterinary samples from Nigeria, finding high susceptibility to itraconazole and voriconazole across species.

The paper identifies conidial surface proteins in Aspergillus fumigatus and shows their role in immune evasion during infection.

The paper uses population genomics to trace the evolution and environmental acquisition of drug-resistant Aspergillus fumigatus, finding evidence of resistant isolates transmitted from the environment to patients.