Amilcar J. Perez

This study investigates the substrate binding and activation mechanism of FtsW, a bacterial cell wall synthase, using simulations, mutagenesis, and assays, revealing key residues and structural changes involved in catalysis.

This paper identifies SddA, a periplasmic deacetylase that modulates daughter cell separation in E. coli by modifying denuded peptidoglycan strands, and links its function to amidase activation.

This paper shows FtsZ treadmilling acts as a template and conveyor to organize cell wall synthesis during bacterial division, with roles changing over time.

This study shows that the CRY2/CIB1 system can be used to precisely control protein localization in E. coli, enabling manipulation of cellular functions like cytokinesis.

This study identifies three types of single-molecule motions of PG synthesis proteins in Streptococcus pneumoniae, revealing zonal, circumferential movement of core elongasome proteins and distinct behaviors of aPBP1a and MpgA.