Malcolm E. Winkler

This study maps tRNA modifications in Streptococcus mutans and S. pneumoniae, revealing shared losses and clade-specific adaptations in modification genes and metabolic strategies.

This paper identifies the pneumococcal S protein as essential for resisting host antimicrobials by coordinating cell wall modification and repair through interactions with PBP1a and PgdA.

This study identifies the enzymatic function of PcsB, a peptidoglycan hydrolase in Streptococcus pneumoniae, showing it cleaves Lys-containing, amidated peptidoglycan and is regulated by structural changes.

The paper identifies glycosylation of serine/threonine-rich IDRs in streptococcal membrane proteins and shows its role in biofilm formation.

This study shows that the CRY2/CIB1 system can be used to precisely control protein localization in E. coli, enabling manipulation of cellular functions like cytokinesis.

This paper identifies five CiaR-controlled Ccn sRNAs in S. pneumoniae that modulate Zn resistance and virulence by regulating metal homeostasis and detoxification mechanisms.

This study identifies three types of single-molecule motions of PG synthesis proteins in Streptococcus pneumoniae, revealing zonal, circumferential movement of core elongasome proteins and distinct behaviors of aPBP1a and MpgA.

This paper identifies a novel pathway for mnm5s2U synthesis in Gram-positive bacteria, revealing alternative biosynthetic mechanisms involving the MnmL enzyme.