Christopher A. Guevara

This study investigates how the LRRK2-G2019S mutation affects sex-specific anxiety-like behaviors and neural activity in response to chronic stress in mice.

This study shows that the LRRK2-G2019S mutation alters AMPAR trafficking and composition in striatal projection neurons, specifically affecting GluA1 subunits and impairing synaptic plasticity.

This study investigates the development of prefrontal corticostriatal connectivity in mice, showing that axons target their zones early and synapses do not undergo extensive pruning, with Cdh8 playing a role in behavioral outcomes.

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

This study shows that a single dose of the psychedelic DOI causes long-lasting epigenetic and synaptic changes in mice, linked to antidepressant effects and potential risks for psychiatric disorders.

This study shows that LRRK2-G2019S mutation alters behavioral and synaptic responses to acute social stress in mice, suggesting impaired adaptive plasticity in neural circuits linked to psychopathology.