Bohan Zhu

The paper maps gene expression, chromatin accessibility, and DNA methylation in developing human brain cells to understand regulatory interactions and their role in disease.

The paper develops ChromE-seq to study 3D chromatin architecture in fetal hematopoiesis, finding that T21 disrupts B-lineage development by altering chromatin connectivity and regulatory circuits.

This study shows that Uhrf1 loss causes DNA methylation loss and chromatin disruption in mouse embryos, leading to developmental failure and altered lineage specification.

The paper introduces ME-seq, a technology that profiles DNA methylation, gene expression, and chromatin accessibility in single nuclei, revealing early microglial priming in Alzheimer's disease.

The paper develops an integrative sequencing strategy to catalog NRXN1 isoforms across human brain tissues and hiPSC organoids, revealing cell-type-specific splicing patterns and therapeutic potential of ASO targeting.

This study develops a method to generate diverse GABAergic neurons from PSCs using TFs and signaling inhibition, showing distinct subtype compositions and disease relevance.

The paper identifies epigenetic changes in frontal cortex of schizophrenia patients, showing antipsychotic treatment reverses some alterations and amplifies age effects.

This paper introduces Drop-BS, a droplet-based microfluidic method for single-cell bisulfite sequencing, enabling high-throughput DNA methylome profiling of up to 10,000 cells in 2 days.

This paper introduces a method to map spatial epigenomic variations in brain tissue at a centimeter scale, revealing dynamic changes in specific brain regions due to seizures.

The paper introduces native MOWChIP-seq, a low-input ChIP-seq method, and applies it to study protein binding differences between mouse brain regions.

This study shows that a single dose of the psychedelic DOI causes long-lasting epigenetic and synaptic changes in mice, linked to antidepressant effects and potential risks for psychiatric disorders.