Giada Finocchio

This study investigates the mechanism of transposon excision by type I-F CRISPR-associated transposases using structural and biochemical analyses.

This study uses cryo-EM to reveal the structural mechanism of RNA-guided DNA integration by PseCAST, providing insights for engineering DNA insertion systems.

The paper identifies an Asgard archaeal Argonaute, HrAgo1, that performs RNA-guided RNA silencing, bridging the gap between prokaryotic and eukaryotic Argonaute mechanisms.

This study reveals how SPARTA, a prokaryotic immune system, is activated by target DNA through structural changes that enable oligomerization and catalytic activity.