Daan C. Swarts

The paper isolates lactate-resistant Lactococcus lactis variants using stressostat cultivation and identifies RNA polymerase mutations as key drivers of resistance through proteome changes.

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.

The paper identifies an Asgard archaeal Argonaute, HrAgo1, that performs RNA-guided RNA silencing, bridging the gap between prokaryotic and eukaryotic Argonaute mechanisms.

This study reveals how SPARTA, a prokaryotic immune system, is activated by target DNA through structural changes that enable oligomerization and catalytic activity.

This study characterizes CbAgo, a mesophilic prokaryotic Argonaute that enables DNA-guided DNA cleavage at moderate temperatures using specific siDNA guides.