Martin Jínek

This study determines the atomic structure of the human tRNA-ligase complex and reveals its assembly mechanism and functional implications.

This study investigates the mechanism of transposon excision by type I-F CRISPR-associated transposases using structural and biochemical analyses.

This study uses cryo-EM to reveal the structural mechanism of RNA-guided DNA integration by PseCAST, providing insights for engineering DNA insertion systems.

The paper shows that forked DNA activates a helicase-nuclease immune complex in type III Druantia through enzymatic processing, enabling phage defense without host toxicity.

This study investigates how uridylation mediates RNA decay in Drosophila by showing how Tailor generates oligo(U) intermediates and how Dis3l2 decodes these to initiate decay.

This paper identifies Ashwin as a nuclear import factor for the tRNA ligase complex and shows that FAM98 paralogs determine its subcellular localization for tRNA biogenesis and UPR.

This paper develops a modular probiotic system in Escherichia coli Nissle1917 that detects nitric oxide and secretes anti-TNF nanobodies to mitigate gut inflammation.

The paper identifies an Asgard archaeal Argonaute, HrAgo1, that performs RNA-guided RNA silencing, bridging the gap between prokaryotic and eukaryotic Argonaute mechanisms.

This study uses cryo-EM to elucidate the mechanism of plasmid elimination by the DdmDE defense system in Vibrio cholerae.

This study characterizes CbAgo, a mesophilic prokaryotic Argonaute that enables DNA-guided DNA cleavage at moderate temperatures using specific siDNA guides.

This study shows that covalently linking a DNA repair template to the CRISPR/Cas9 complex increases HDR efficiency 23-fold compared to NHEJ.