Thales Kronenberger

The paper investigates how human-targeted drugs alter regulatory networks in Salmonella Typhimurium, revealing non-antibiotic compounds reshape virulence and antibiotic resistance through specific transcriptional responses.

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

The paper uses machine learning to identify novel HDAC6/AKT2 inhibitors for myeloid cancer treatment, finding compounds with potent anticancer activity.

This study develops selective MST3/4 kinase inhibitors and demonstrates their distinct cellular effects compared to MST1/2 inhibition.