Mattia Quattrocelli

This study identifies a multimodal transcriptional response in denervated skeletal muscle, revealing altered cholesterol homeostasis and its impact on myofiber size.

This study identifies Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle, using a human SNP rs6190 in mice and human datasets.

This study identifies a human GR variant, rs6190, that increases cholesterol and atherosclerosis risk by enhancing GR activity in mice and human cells.

This study identifies the cardiomyocyte-specific GR-KLF15 axis as a circadian-regulated regulator of glucose metabolism, showing that timed glucocorticoid administration improves cardiac function in diabetic mice.

This study shows that intermittent glucocorticoid treatment rescues both energy and mass in aging-related sarcopenia via the PGC1alpha-Lipin1 pathway in muscle cells.