Zane Kliesmete

CroCoNet quantitatively compares gene regulatory networks across species, identifying conserved and diverged modules, including POU5F1's rewired network in great apes.

The paper investigates how pleiotropy affects the evolution of cis-regulatory elements, finding that more pleiotropic elements show greater conservation in function despite lower sequence conservation.

The paper profiles the transcriptome of striatal subregions in mice during learning stages to identify molecular changes and provides a web tool for exploring the data.

This study evaluates background noise in single-cell RNA-seq data and assesses methods for its removal, finding that CellBender performs best for marker gene detection.