Author

Natalie Landon‐Brace

University of TorontoORCID 0000-0001-7021-8716Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alison P. McGuiganiD· 2 shared Ileana L. CoiD· 2 shared Jose L. CadavidiD· 2 shared Michelle NurseiD· 2 shared Aleksandra FominaiD· 1 shared Brendan T. InnesiD· 1 shared Cassidy M Tan· 1 shared Chengxin YuiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Alison P. McGuiganORCID

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2 papers

Recent·Most cited

Cancer BiologyScientific ReportsPeer-reviewedJul 2, 2025

Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes

Natalie Landon‐Brace, Simon Latour, Brendan T. Innes…·Alison P. McGuigan

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

7 citations

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BioengineeringbioRxivPreprintJul 13, 2023

An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer

Ileana L. Co, Chengxin Yu, Sara Lamorte…·Alison P. McGuigan

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.

4 citations

humanorganoid / primary culture

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