Alison P. McGuigan

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

This paper develops a cost-effective method for manufacturing 3D cancer models using vacuum thermoforming, enabling high-resolution imaging of tumor cell behavior.

The paper introduces Cytomarker, an interactive platform for designing antibody panels using single-cell RNA-seq data, and validates it on human mammary tissue subpopulations.

This study identifies EHMT2 as a key regulator of CAF hyperproliferation and pro-invasive behavior, showing its inhibition reprograms CAFs to a less aggressive state.

This paper develops a cryopreservation method for myoblasts in paper-based scaffolds, enabling inter-laboratory studies of skeletal muscle health.

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.