Author

Michelle Nurse

University of TorontoORCID 0009-0007-4369-2712Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Alison P. McGuiganiD· 3 shared Ileana L. CoiD· 2 shared Jose L. CadavidiD· 2 shared Natalie Landon‐BraceiD· 2 shared Tracy L. McGahaiD· 2 shared Aleksandra FominaiD· 1 shared Brendan T. InnesiD· 1 shared C. H. ArrowsmithiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

Alison P. McGuiganORCID

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3 papers

Recent·Most cited

Cancer BiologyScientific ReportsPeer-reviewedJul 2, 2025

Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes

Natalie Landon‐Brace, Simon Latour, Brendan T. Innes…·Alison P. McGuigan

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

7 citations

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Cancer BiologyBiomaterialsPeer-reviewedOct 5, 2024

EHMT2/G9a-Inhibition Reprograms Cancer-Associated Fibroblasts (CAFs) to a More Differentiated, Less Proliferative and Invasive State

Nila C. Wu, Rene Quevedo, Michelle Nurse…·Alison P. McGuigan

This study identifies EHMT2 as a key regulator of CAF hyperproliferation and pro-invasive behavior, showing its inhibition reprograms CAFs to a less aggressive state.

8 citations

humanbulk RNA-seq

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BioengineeringbioRxivPreprintJul 13, 2023

An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer

Ileana L. Co, Chengxin Yu, Sara Lamorte…·Alison P. McGuigan

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.

4 citations

humanorganoid / primary culture

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