PhysiologybioRxivPreprint
MCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure
Joanne F. Garbincius, Timothy S. Luongo, Jonathan P. Lambert…·John W. Elrod
This study uses gain- and loss-of-function models of the mitochondrial calcium uniporter to show that mCa2+ uptake is essential for early cardiac contractility but harmful under sustained stress.
6 citations