Jean‐François Côté

This study shows that inhibiting PAK2 in endothelial cells reduces tumor angiogenesis and enhances immune cell infiltration via CXCL10 secretion.

This study shows Dock8 regulates mechanosensitive actin redistribution in immune cells, maintaining cohesion and protecting the nucleus during migration through confined environments.

The paper investigates how multiple FGFR1 mutations affect tumorigenic mechanisms in glioneuronal tumors by analyzing their interactomes and functional impacts.

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

This study identifies GID4 as a substrate receptor of the hGID E3 ligase complex that targets ARHGAP11A for degradation, thereby regulating cell migration.

This study shows GAS6 and AXL reduce insulin sensitivity by altering insulin signaling and increasing insulin receptor trafficking to endosomes.

The paper maps the interactome of ARF and ARL proteins using BioID, identifies new localizations, and reveals functional roles of ARL14 in activating PLD1 and cargo trafficking.

The paper identifies C1orf112 as a novel regulator of interstrand crosslinks that decreases FIGNL1-RAD51 interaction, impairing homology-directed repair.

The paper shows GFI1 recruits the NuRD complex to open chromatin regions in myeloid progenitors, influencing chromatin structure and gene regulation during neutrophil differentiation.

This study identifies POGZ as a regulator of HP1-dependent DNA repair, showing its role in homology-directed repair and its clinical relevance to White Sutton syndrome.