Author

C. Thomas Appleton

Western UniversityORCID 0000-0001-7148-0767Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:rat· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Garth BlackleriD· 2 shared Alexander J. KnightsiD· 1 shared Benoit FisetiD· 1 shared Dariana Ocica· 1 shared Easton C. FarrelliD· 1 shared Ermina HadziciD· 1 shared Frank BeieriD· 1 shared HanYu Jiang· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersPhysiology

Garth BlacklerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologyeLifePeer-reviewedFeb 19, 2025

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

Alexander J. Knights, Easton C. Farrell, Olivia M. Ellis…·Tristan Maerz

This study identifies synovial macrophage subpopulations and their regulation by M-CSF signaling in a mouse model of post-traumatic osteoarthritis.

12 citations

𝕏 PostBluesky

PhysiologybioRxivPreprintSep 26, 2024

Metabolic Stress Accelerates Dysregulated Synovial Macrophage-Fibroblast Communication and Htra1 Overproduction in Osteoarthritis

Garth Blackler, Joseph Daniel Klapak, Qinli Guo…·C. Thomas Appleton

This study shows metabolic stress worsens osteoarthritis by altering synovial macrophage-fibroblast communication and increasing Htra1 expression.

1 citation

𝕏 PostBluesky

GeneticsApplied SciencesPeer-reviewedJul 31, 2021

Genetic deletion of interleukin-15 is not associated with major structural changes following experimental post-traumatic knee osteoarthritis in rats

Ermina Hadzic, Garth Blackler, Holly Dupuis…·Frank Beier

This study investigates the role of IL-15 in post-traumatic knee osteoarthritis in rats and finds no significant structural differences between IL-15 deficient and wild-type rats.

1 citation

ratstatistical model

𝕏 PostBluesky