Easton C. Farrell

This study identifies PIEZO1 as a critical mediator of myofibroblast activation and fibrosis in post-traumatic osteoarthritis through mechanosensing mechanisms.

This study shows that repeated NGF injections into mouse knees cause multiple OA-like features without cartilage damage.

This study investigates how synovial microenvironment stiffness changes during OA progression and how it affects fibroblast and macrophage behavior through mechanosignaling and cell-cell interactions.

This study identifies synovial macrophage subpopulations and their regulation by M-CSF signaling in a mouse model of post-traumatic osteoarthritis.