Peltier Johann

This study identifies a family of small proteins regulated by c-di-GMP riboswitches that mediate sporulation in C. difficile, showing their role in spore formation and developmental regulation.

This study shows that TcdE holin is essential for toxin secretion and virulence in C. difficile, as tcdE mutants exhibit reduced toxin release and less virulence in mice.

The paper identifies a new AbiF-like system in C. difficile and shows its regulation by a non-coding RNA through RNA-protein interactions.

This study shows that cephalosporin resistance in C. difficile is due to inhibition of D,D-carboxypeptidases, not L,D-transpeptidases, and highlights the plasticity of PG biosynthesis.

This study shows that CDT toxin from Clostridioides difficile induces biofilm-like microcolonies, increasing colonization and persistence in intestinal models and infected mice.

The paper develops regulatory, metabolic, and integrated models for C. difficile to understand its colonization mechanisms and interactions with the gut microbiota.