Shantanu Chowdhury

This study presents whole-genome and transcriptome analyses of breast tumors from India, identifying novel mutations, copy number alterations, and subtypes with clinical implications.

This paper shows telomere length regulates hTERT expression by modulating TRF2 binding and PRC2-mediated repression, revealing a self-regulatory mechanism in cancer.

This study shows TRF2's non-telomeric function is critical for maintaining neural stem cell identity by repressing differentiation genes through PRC2 recruitment and G4 motif binding.

The paper inserts G-quadruplex DNA sequences into cells and shows they increase chromatin looping and gene activation over long distances.

This paper introduces an impedance-based biosensor for rapid, label-free detection of cancer-associated cfDNA with high sensitivity and specificity across multiple cancer types.

This study identifies FDA-approved drugs that bind G-quadruplexes in SARS-CoV-2 genomes, showing significant inhibition of viral replication in hamsters and cell cultures comparable to Remdesivir.