Yoshifumi Yamaguchi

The paper identifies dynamical signatures and a mathematical principle underlying the transition from normothermia to hypothermia in mammals.

This study creates a transcriptomic atlas of the Syrian hamster preoptic area using snRNA-seq and spatial transcriptomics, comparing seasonal and hibernation states.

This paper identifies a preoptic circuit involving Crh-expressing neurons that initiates rewarming from torpor in mice and shows similar activation in hibernators.

TOHMIN quantifies hibernation patterns from body temperature data, revealing diet and sex effects on arousal duration and pre-hibernation period.

This study shows that cold stress suppresses myogenesis in skeletal muscle stem cells of hibernating Syrian hamsters, delaying muscle regeneration without affecting cell viability.

This study shows chronic social defeat stress in mice causes metabolic dysregulation through cerebellar pathways, linking psychological stress to type II diabetes.

This study identifies Gpx4 and ferroptosis-suppressing pathways as key to cold resistance in hibernator cells, showing their potential to enhance cold tolerance in non-hibernators.

This study shows that SCN neurons maintain circadian rhythms at moderate hypothermia but suspend them at deep hypothermia, with Ca2+ rhythms resetting faster than transcriptional rhythms upon rewarming.