Jan Fabio Nickels

The paper investigates how HP1 binding represses transcription at chromocenters and persists during decondensation, using a 1D lattice model to explain chromatin state transitions.

This study shows that H3.3K36M mutation reduces epigenetic memory and promoter methylation by disrupting the conversion of H3K9me3 domains into DNA methylation.

The paper analyzes confinement mechanisms for epigenetic modifications of nucleosomes using stochastic dynamic models and finds that intermediate states and long-range negative feedback enhance robustness and confinement.