Joydeb Sinha

The paper investigates chromatin state transitions during epigenetic memory formation by analyzing single-cell gene expression and chromatin structure changes after repressor recruitment and release.

This study shows that H3.3K36M mutation reduces epigenetic memory and promoter methylation by disrupting the conversion of H3K9me3 domains into DNA methylation.

The paper measures how combinations of transcriptional activators and repressors affect gene expression and uses this to create a tunable synthetic transcription factor.

The paper studies how gene silencing and reactivation spread between neighboring genes in single cells, finding different dynamics based on chromatin regulators and insulator elements.