GEORGE V. THOMAS

MiroSCOPE is an AI platform for annotating functional tissue units in digital pathology, enabling efficient annotation of over 71,900 units across prostate cancer samples.

The paper analyzes germline mutations in TNBC patients in India and identifies BRCA1/2 as the most common mutated genes, with novel mutations and a higher proportion of variants of uncertain significance in non-BRCA genes.

This study shows that tigecycline inhibits mitochondrial translation in RCC, disrupts bioenergetics, and synergizes with entinostat to enhance anti-tumor effects.

This study constructs the Prostate Cancer Cell Atlas by analyzing ~710,000 single cells from 197 human samples to characterize cell states and dynamics across prostate cancer progression stages.

This study compares transcriptomes of canine and human prostate cancers to identify genes associated with castration resistance, finding shared molecular features in both species.

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

This study creates a multimodal tumor atlas to analyze how metastatic HR+ breast cancers adapt to CDK4/6 inhibitors, revealing mechanisms like mTORC1 activation and immune microenvironment changes.