Yamei Hu

This study identifies C9orf50 as a spliceosome regulator that, when targeted, converts immunologically cold tumors to hot ones by enhancing immunogenicity and T cell recruitment.

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.