Author

Frédérique Larroquette

Montreal Neurological Institute and HospitalORCID 0000-0001-7423-6911Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Edward A. FoniD· 2 shared Esther del Cid‐PelliteroiD· 2 shared Irina ShlaiferiD· 2 shared Jean‐François TrempeiD· 2 shared Thomas GoiraniD· 2 shared Thomas M. DurcaniD· 2 shared Wen LuoiD· 2 shared Amitha MuraleedharaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Edward A. FonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Molecular BiologyNeurobiology of DiseasePeer-reviewedJun 11, 2026

N-terminal acetylation reduces α-synuclein pathology in models of Parkinson's disease

Esther del Cid‐Pellitero, Thomas Goiran, Zaid A.M. Al‐Azzawi…·Edward A. Fon

This study shows that N-terminal acetylation of α-synuclein reduces aggregation, uptake, seeding, and toxicity in Parkinson's disease models.

1 citation

mouseproteomics

𝕏 PostBluesky

Cell BiologyCommunications BiologyPeer-reviewedOct 6, 2025

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

Benoît Vanderperre, Amitha Muraleedharan, Marie‐France Dorion…·Edward A. Fon

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

18 citationstop 2%

humangenetic perturbation / CRISPR

𝕏 PostBluesky