Author
Montreal Neurological Institute and HospitalORCID 0000-0001-5838-8798Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Esther del Cid‐Pellitero, Thomas Goiran, Zaid A.M. Al‐Azzawi…·Edward A. Fon
This study shows that N-terminal acetylation of α-synuclein reduces aggregation, uptake, seeding, and toxicity in Parkinson's disease models.
Benoît Vanderperre, Amitha Muraleedharan, Marie‐France Dorion…·Edward A. Fon
This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio…·Adriano Aguzzi
The paper uses CRISPR screens to identify OXR1 and EMC4 as modifiers of α-synuclein aggregation in Parkinson's disease and related synucleinopathies.
Jace Jones-Tabah, Kathy He, Nathan C. Karpilovsky…·Edward A. Fon
This study investigates the role of cathepsin B in Parkinson's disease by analyzing genetic variants and manipulating catB function in cell models to assess its impact on lysosomal activity and alpha-synuclein clearance.