Kevin I. Watt

The paper identifies a compound that selectively promotes cardiomyocyte proliferation through specific cell cycle mechanisms without affecting other cell types.

This study uses proteomics to identify a cryptic JPH2 loss-of-function in a paediatric DCM patient, revealing a novel mechanism of recessive disease.

This paper demonstrates that nanoclusters of integrin-, syndecan-, and dystroglycan-binding peptides on biomaterial surfaces enhance myoblast adhesion, proliferation, and differentiation in dystrophin-deficient cells.

This study shows that maturing human cardiac organoids enhances disease modeling and drug discovery by mimicking in vivo development and enabling therapeutic testing for DSP cardiomyopathy.

This study characterizes the skeletal muscle arginine methylome in health and disease, revealing significant remodeling in ALS and identifying potential therapeutic targets.

This study benchmarks spatial transcriptomics methods by comparing 6 SVG identification tools across 14 datasets, revealing discrepancies in results.

VR-Omics automates integration of multi-slice spatial transcriptomics data in 2D and 3D, revealing dysregulated metabolic networks in paediatric cardiac rhabdomyomas.

The paper identifies UFMylation as a negative regulator of skeletal muscle function through proteome-wide systems genetics in mice and validates it in a disease model.

This study demonstrates that long-term tissue-specific Cas9 expression in mice does not cause detrimental health effects or metabolic changes, supporting its use for gene-specific studies.