Paul Gregorevic

This paper demonstrates that nanoclusters of integrin-, syndecan-, and dystroglycan-binding peptides on biomaterial surfaces enhance myoblast adhesion, proliferation, and differentiation in dystrophin-deficient cells.

The paper quantifies UFMylation sites in mouse tissues and ALS patient biopsies, finding increased myosin UFMylation in ALS.

This study identifies Rac1 as a key regulator of exercise training adaptations by showing its role in protein synthesis, glycogen resynthesis, and running capacity in mice and human muscle.

The paper identifies UFMylation as a negative regulator of skeletal muscle function through proteome-wide systems genetics in mice and validates it in a disease model.

This study demonstrates that long-term tissue-specific Cas9 expression in mice does not cause detrimental health effects or metabolic changes, supporting its use for gene-specific studies.

This study shows that ACTN3 genotype affects skeletal muscle mass regulation and response to dexamethasone, with -actinin-3 deficiency reducing atrophy signaling and protecting against muscle wasting in female mice.