Alissa C. Rothchild

This study shows that ferroptosis, a form of cell death, is enhanced by a virulent Mtb strain, SA161, and inhibiting it reduces bacterial spread in mice.

This study compares human and murine macrophage responses to Mtb infection, identifying shared and distinct immune pathways and cytokine expression patterns between alveolar and monocyte-derived macrophages.

This study shows NRF2 inhibits MHC II expression in alveolar macrophages during Mtb infection, impairing CD4+ T cell activation and host immunity.

This study identifies TDM's mechanism of inhibiting phagosome maturation by interacting with SNARE proteins, promoting M. tuberculosis growth.

This study shows alveolar macrophages have reduced LPS responses due to low TLR4/CD14 surface expression and lack IL-10 production, which is enhanced by type I IFN.

Alveolar macrophages infected with Mtb in vivo up-regulate an Nrf2-dependent antioxidant response instead of a pro-inflammatory response, impairing bacterial control.