Volker Busskamp

This study shows that activating ERV-W in human glutamatergic neurons disrupts postsynaptic organization and synaptic function.

The paper shows TET3 and MECP2 interact to regulate neuronal maturation, with TET3 critical for functional development and MECP2 inhibiting TET3 activity.

The paper validates ephaptic coupling in human neuronal circuits using a reproducible in vitro method, showing reduced action potential velocity and increased synchronization.

This study develops a high-throughput method to generate reliable human brain organoids for modeling microcephaly, glioma invasion, and drug screening.

The paper identifies a new subgroup of light-driven sodium pumps with an additional glutamic acid residue that reduces pH sensitivity for sodium transport.

This study shows that cellular senescence promotes progenitor cell expansion during axolotl limb regeneration by creating a pro-proliferative niche and modulating Wnt signaling.

This study shows that human photoreceptor cells transplanted into human retina organoids integrate structurally, forming clusters with cone and rod photoreceptors and host cell contacts.

This paper demonstrates that transplanted human photoreceptors from iPSC retinal organoids extensively incorporate into a murine cone degeneration model, leading to improved maturation, polarisation, and functional integration.

This study shows human brain organoids can form bilateral optic vesicles with cellular diversity and functionality, including light-responsive photoreceptors and neuronal networks.

The paper develops a holographic optogenetic platform to study long-term functional connectivity in human stem-cell-derived neuronal networks.