Author

Aruljothi Mariappan

Jena University HospitalORCID 0000-0001-5286-9806Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Jay GopalakrishnaniD· 4 shared Elke GabrieliD· 3 shared Anand RamaniiD· 2 shared Dhanasekaran RathinamiD· 2 shared Giovanni PasquiniiD· 2 shared Giuliano CallainiiD· 2 shared Maria Giovanna RiparbelliiD· 2 shared Olivier GoureauiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersDevelopmental Biology

Jay GopalakrishnanORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 1, 2025

CCB79 is a primate-specific cilium initiation factor essential to maintain neural progenitor diversity in developing brain tissue.

Dhanasekaran Rathinam, Vaibhav Jadhav, Seema Wasim…·Jay Gopalakrishnan

This study identifies CCB79 as a primate-specific protein essential for maintaining neural progenitor diversity in developing brains by regulating ciliogenesis.

DOI 10.1101/2025.08.01.668123

humanmouse

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Cell BiologyNature CommunicationsPeer-reviewedDec 19, 2024

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion, and drug screening

Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau…·Jay Gopalakrishnan

This study develops a high-throughput method to generate reliable human brain organoids for modeling microcephaly, glioma invasion, and drug screening.

59 citationstop 2%

humanorganoid / primary culture

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Developmental BiologybioRxivPreprintNov 16, 2022

Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease

Tao Cheng, Aruljothi Mariappan, Ewa Langner…·Moe R. Mahjoub

This study shows that inhibiting centrosome clustering reduces cyst growth and improves kidney function in ADPKD by activating p53-mediated apoptosis.

DOI 10.1101/2022.11.16.516801

mousehuman

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Developmental BiologyCell stem cellPeer-reviewedAug 17, 2021

Human brain organoids assemble functionally integrated bilateral optic vesicles

Elke Gabriel, Walid Albanna, Giovanni Pasquini…·Jay Gopalakrishnan

This study shows human brain organoids can form bilateral optic vesicles with cellular diversity and functionality, including light-responsive photoreceptors and neuronal networks.

180 citationstop 1%

humanexperimental assay

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