Author

Melissa R. Soto

The University of Texas at AustinORCID 0000-0001-8233-2567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Debadyuti GhoshiD· 2 shared Mae M. LewisiD· 2 shared Rashmi P. MohantyiD· 2 shared Yuting PaniD· 2 shared Esther Y. MaieriD· 1 shared Jasmim LealiD· 1 shared Riyad F. AlzhraniiD· 1 shared Sophie Peng· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersBioengineering

Debadyuti GhoshORCID

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2 papers

Recent·Most cited

BioengineeringBioconjugate ChemistryPeer-reviewedSep 3, 2025

Electrostatic-driven Interactions Enhance Intratumoral Retention and Antitumor Efficacy of Immune Checkpoint Blockade Antibodies

Rashmi P. Mohanty, Yuting Pan, Mae M. Lewis…·Debadyuti Ghosh

Peptide-conjugated immune checkpoint blockade antibodies show enhanced antitumor efficacy through electrostatic interactions with tumor ECM, increasing CD8+ T cell infiltration and reducing regulatory T cells.

2 citations

humanproteomics

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BioengineeringbioRxivPreprintSep 13, 2023

Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

Melissa R. Soto, Mae M. Lewis, Jasmim Leal…·Debadyuti Ghosh

The paper identifies a peptide that enhances mRNA lipid nanoparticle delivery to CF lung epithelial cells, showing improved mRNA expression in vitro and in vivo.

DOI 10.1101/2023.09.13.557559

humanbulk RNA-seq

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