Alok V. Joglekar

The paper identifies a commensal-specific CD8αβ+ T cell population in the intestine driven by a single commensal species and shows how epithelial signals regulate their differentiation and restraint.

The paper identifies a microenvironment-driven neoantigen, C19S, in type 1 diabetes that activates persistent memory T cells through HLA-DQ8 recognition.

SWING is a novel interaction language model that predicts peptide:MHC interactions and protein-protein interaction disruptions using sequence data.

SLIDE identifies significant interacting latent factors in multi-omic datasets, revealing biological insights in systemic sclerosis, spatial transcriptomics, and T1D models.

This study shows that TCR immunotherapy suppresses HIV in humanized mice but drives viral evolution under selection pressure.