Sean Michael Howard

This study shows that aging impairs mesenchymal stem cells by reducing osteogenesis, increasing adipogenesis, and decreasing mitochondrial mechanical responsiveness.

This study shows that low-intensity vibrations cause nuclear motion and cytoskeletal changes in mesenchymal stem cells, independent of matrix strain, leading to transcriptional activation.

This study shows that disrupting the LINC complex in bone progenitor cells reduces exercise-induced osteoid deposition but not bone quality in mice.

This paper develops and characterizes a low-intensity vibrational bioreactor for microgravity studies on the International Space Station.

This study shows that increased mechanical strain is not necessary for MSC response to vibration in bone marrow analogs, as lower bone volume fractions still showed reduced collagen and F-actin despite higher strains.

This study examines the effect of Osterix-driven LINC complex disruption on bone microarchitecture in mice, finding reduced bone quality at 8 weeks but no significant change after 6 weeks of voluntary running.

This study investigates whether low-intensity vibration affects microtubule dynamics in vitro and finds no significant changes compared to controls, unlike Taxol treatment.