Edward Seto

This study shows that inhibiting HDAC10 increases SPARC expression, which suppresses melanoma growth and restores sensitivity to BRAF inhibitors.

This study shows that HDAC11 suppresses thermogenic programs in adipose tissue via BRD2, leading to improved metabolic outcomes in HDAC11-deficient mice.

This study identifies HDAC11 as a key regulator of metabolism and obesity, showing that its deficiency prevents high-fat diet-induced obesity and metabolic syndrome in mice.