Theofilos Chalkiadakis

The paper characterizes regulatory variants in human neurons using lentiMPRA and shows that variant effects are influenced by regulatory element activity and sequence context, not population frequency.

The paper identifies location-specific transcriptional differences in tumor-infiltrating Treg cells across CRC metastases and links these to poor patient prognosis.

This study shows that glycolytic reprogramming in JIA CD4+ T cells drives epigenetic changes linked to inflammation, with potential therapeutic implications.

This study shows IFNγ reprograms intestinal epithelial organoids to secrete CXCL11, which enhances T cell migration without affecting T cell activation.