Paul James Coffer

The paper identifies location-specific transcriptional differences in tumor-infiltrating Treg cells across CRC metastases and links these to poor patient prognosis.

This study identifies a novel form of autophagy in CD4+ T cells that is independent of ULK1/2 and occurs alongside mTORC1 activation, supporting proliferation and cytokine production.

This study shows that nanofibrillar cellulose hydrogels preserve T cell function better than Matrigel or basement membrane extract in 3D cultures.

This study shows that glycolytic reprogramming in JIA CD4+ T cells drives epigenetic changes linked to inflammation, with potential therapeutic implications.

This study shows CRC tumor organoids induce Treg cells via TGFβ-dependent differentiation, with distinct transcriptional profiles and prognostic relevance in CRC patients.

This study shows IFNγ reprograms intestinal epithelial organoids to secrete CXCL11, which enhances T cell migration without affecting T cell activation.