Author

Cynthia Lisanne Frederiks

University Medical Center UtrechtORCID 0009-0004-6112-6798Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Enric MocholíiD· 4 shared Paul James CofferiD· 4 shared Onno KranenburgiD· 3 shared Sonia Aristín Revilla· 3 shared Stefan PrekovićiD· 3 shared Alessandro Cutilli· 2 shared Caroline A. LindemansiD· 2 shared Theofilos ChalkiadakisiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersImmunology

Enric MocholíORCID

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4 papers

Recent·Most cited

ImmunologyCancer LettersPeer-reviewedJun 11, 2026

Site-dependent Treg cell transcriptional reprograming in a metastatic colorectal cancer model holds prognostic significance

Sonia Aristín Revilla, André Verheem, Cynthia Lisanne Frederiks…·Paul James Coffer

The paper identifies location-specific transcriptional differences in tumor-infiltrating Treg cells across CRC metastases and links these to poor patient prognosis.

DOI 10.1016/j.canlet.2026.218656

mousebulk RNA-seq

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ImmunologyiSciencePeer-reviewedJul 30, 2025

Basement membrane hydrogels dampen CAR-T cell activation: nanofibrillar cellulose gels as alternative to preserve T cell function in 3D cell cultures.

Sonia Aristín Revilla, Alessandro Cutilli, Eugenia Cambiaso…·Marta Cuenca

This study shows that nanofibrillar cellulose hydrogels preserve T cell function better than Matrigel or basement membrane extract in 3D cultures.

9 citations

mousehuman

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ImmunologyiSciencePeer-reviewedJan 18, 2025

Tumor-derived colorectal cancer organoids induce a unique Treg cell population through direct modulation of CD4+ T cell differentiation.

Sonia Aristín Revilla, Cynthia Lisanne Frederiks, Stefan Preković…·Paul James Coffer

This study shows CRC tumor organoids induce Treg cells via TGFβ-dependent differentiation, with distinct transcriptional profiles and prognostic relevance in CRC patients.

14 citationstop 4%

mousehuman

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ImmunologyJournal of Leukocyte BiologyPeer-reviewedSep 19, 2024

IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration

Alessandro Cutilli, Suze A. Jansen, Francesca Paolucci…·Paul James Coffer

This study shows IFNγ reprograms intestinal epithelial organoids to secrete CXCL11, which enhances T cell migration without affecting T cell activation.

11 citations

humanproteomics

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