Meghan L. Bucher

This paper identifies selective SV2C ligands using AI-enhanced virtual screening and experimental validation, finding 22 active molecules with high selectivity over SV2A and SV2B.

This study presents cryo-EM structures of SV2C and its ligands, revealing structural differences that explain ligand selectivity and impact dopamine release.

This study investigates how dopamine production and storage affect body size, development, and behavior in C. elegans, finding that increased dopamine production can rescue deficits caused by reduced dopamine sequestration.

This study shows that SV2C enhances dopamine and neurotoxicant storage in vesicles, reducing dopaminergic neuron vulnerability.

This study investigates the effects of reduced VMAT activity in C. elegans, showing increased sensitivity to MPP+ and metabolic changes, suggesting conserved monoamine function and potential for metabolomics in disease research.