Kelly Kersten

This study shows that disrupting the ARID1A-containing SWI/SNF complex in tumor-associated macrophages enhances immunotherapy response by reprogramming their gene expression and improving checkpoint blockade efficacy.

This study identifies NCOR2 as an epigenetic repressor of MHC class I expression in breast cancer, promoting metastasis by inhibiting immune surveillance.

This study shows that CD206+ macrophages support an anti-tumor network involving cDC1, NK cells, and CD8 T cells, and their depletion impairs tumor control in mice and correlates with poor survival in humans.

ZipSeq maps single-cell transcriptomes in real-time within intact tissues, revealing new gene expression patterns and differentiation trajectories in various biological contexts.