Cancer BiologyFrontiers in OncologyPeer-reviewed
Epigenetic modification and characterization of the MGMT promoter region using CRISPRoff in glioblastoma cells
Remi Weber, Michael Weller, Guido Reifenberger, Flavio Vasella
This study uses CRISPRoff to introduce site-specific CpG methylation in the MGMT promoter of glioblastoma cells, showing reduced MGMT expression and increased temozolomide sensitivity.
6 citations