Guido Reifenberger

This study identifies GALE as a key regulator of glycoproteome remodelling in RAS-driven cancer, showing its role in sialylation and tumorigenicity.

This study shows that EIF4EBP1 is upregulated by MYC in medulloblastoma and linked to poorer patient survival.

The paper identifies tertiary lymphoid structures in brain metastases from different cancer types and links their presence to patient survival.

This study uses CRISPRoff to introduce site-specific CpG methylation in the MGMT promoter of glioblastoma cells, showing reduced MGMT expression and increased temozolomide sensitivity.

This study shows oncogenic RAS signaling suppresses ferroptosis by upregulating GCH1 and BH4, making RAS-driven cancers resistant to ferroptosis-inducing agents.

The paper shows neurons form direct excitatory synapses with brain-metastatic breast and melanoma cancer cells, supporting metastasis and offering new therapeutic targets.

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.

The paper identifies ROS1 fusions in various glioma types through genomic and transcriptomic analysis, showing they are not restricted to specific subtypes.