Wu Han Toh

FALCON optimizes lipid nanoparticles for cell-selective mRNA delivery, improving transfection efficiency and selectivity in vivo.

This paper identifies age-related impairment in systemic mRNA translation as a barrier to mRNA vaccine efficacy and develops an LNP formulation to restore transgene expression and T cell immunity in aged hosts.

This paper introduces a crosslinking method to improve mRNA LNP stability and delivery efficiency, showing enhanced structural integrity and transfection performance in vitro and in vivo.

This study uses machine learning to identify LNP composition parameters that enhance transfection efficiency across cell types and modulate cell type-preferentiality.