Jason Nomburg

This study identifies diverse 2H phosphodiesterases in viruses that selectively degrade cyclic dinucleotides to evade host immune signaling.

The paper develops a CRISPRi-ART system to knock down protein expression in diverse bacteriophages and identifies essential genes, including many with unknown functions.

The paper identifies new viral protein folds and functions by analyzing a database of predicted viral protein structures, revealing conserved immune evasion mechanisms across different viral species.