Krzysztof J. Szkop

RAPPL-Seq enables rapid, high-sensitivity ribosome profiling of scarce samples by improving RPF recovery efficiency and reducing processing time.

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

The paper shows hypoxia induces TSS switching via H3K4me3 changes, altering translation of key metabolic genes like PDK1.

This study shows that TSC2 loss in neural progenitor cells suppresses translation of ASD/NDD-associated transcripts, which can be reversed by inhibiting mTORC1 or MNK1/2.

The paper identifies start-stop elements in 5' UTRs that repress translation by halting ribosomes, showing their prevalence in human genes and impact on cellular processes.

flexiMAP identifies differential alternative polyadenylation in RNA-seq data using beta-regression, outperforming existing methods in sensitivity and specificity.

This study shows estrogen receptor alpha (ER) regulates gene expression by coordinating transcription with translational offsetting, maintaining protein levels despite changes in mRNA abundance.