David J. Papadopoli

This study identifies a lactate-fueled metabolon involving LDHB and HTC that promotes breast cancer metastasis by reprogramming NAD metabolism.

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

The paper shows hypoxia induces TSS switching via H3K4me3 changes, altering translation of key metabolic genes like PDK1.

This study shows that both mTOR activation and inhibition increase H3K27me3 through distinct mechanisms, and this epigenetic change correlates with the anti-proliferative effects of mTOR inhibitors.