Lynne-Marie M Postovit

This study identifies immune dysfunction linked to AP-1 in BCG non-responders with NMIBC, suggesting pre-existing immunosenescence contributes to early recurrence.

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

This study isolates extracellular vesicles from minimal ascites fluid using strong anion exchange magnetic beads, enhancing proteomic depth and identifying new proteins and SERS signatures in ovarian cancer-derived EVs.

This study shows that SMARCA4 loss in endometrial cancer leads to cell state chaos, not stemness, causing dedifferentiation through epigenomic dysregulation.

The paper shows hypoxia induces TSS switching via H3K4me3 changes, altering translation of key metabolic genes like PDK1.

This study compares Thermolysin and Trypsin/LysC proteolysis for enhancing proteomic analysis of ovarian cancer extracellular vesicles, finding Thermolysin improves peptide complexity and identifies unique proteins like Ly6E and NODAL.

The paper shows that analyzing healthcare records and DNA sequences can predict drug effects by treating inhibitory drugs as loss-of-function variants, using data from biobanks like UK Biobank.

This study shows that both mTOR activation and inhibition increase H3K27me3 through distinct mechanisms, and this epigenetic change correlates with the anti-proliferative effects of mTOR inhibitors.

This study investigates post-transcriptional regulation of human NODAL splice variants, showing differential processing and functional distinctions in embryonic stem cells and cancer cells.

This study identifies novel RNAs transcribed from the human NODAL locus, including antisense, circular, and splice variants, highlighting the complexity of NODAL expression.